Pharmacokinetics of Oseltamivir and Oseltamivir Carboxylate in Critically I ll Patients Receiving Continuous Venovenous Hemodialysis and/or Extracorporeal Membrane Oxygenation

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94511/1/phar1151.pd

Real-time Emotional State Detection from Facial Expression on Embedded Devices

From the last decade, researches on human facial emotion recognition disclosed that computing models built on regression modelling can produce applicable performance. However, many systems need extensive computing power to be run that prevents its wide applications such as robots and smart devices. In this proposed system, a real-time automatic facial expression system was designed, implemented and tested on an embedded device such as FPGA that can be a first step for a specific facial expression recognition chip for a social robot. The system was built and simulated in MATLAB and then was built on FPGA and it can carry out real time continuously emotional state recognition at 30 fps with 47.44% accuracy. The proposed graphic user interface is able to display the participant video and two dimensional predict labels of the emotion in real time together.The research presented in this paper was supported partially by the Slovak Research and Development Agency under the research projects APVV-15-0517 & APPV-15-0731 and by the Ministry of Education, Science, Research and Sport of the Slovak Republic under the project VEGA 1/0075/15

Impact of an Intravenous Magnesium Shortage on Potassium Doses in Adult Surgical Patients Receiving Parenteral Nutrition

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141001/1/jpen0688.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141001/2/jpen0688-sup-0001.pd

Consent, wantedness, and pleasure: Three dimensions affecting the perceived stress of and judgements of rape in sexual encounters

Participants conflate consent and wantedness when judging situations as rape (Peterson & Muehlenhard, 2007). Pleasure might also affect how such situations might be appraised by victims, perpetrators, and jurors. In four experiments, participants read vignettes describing sexual encounters that were consensual or not, wanted or unwanted, and pleasurable or not pleasurable. Participants judged whether they thought each situation described rape and how distressing they thought the encounter would be. Wantedness affected perceived distress when consent was given. Wantedness and pleasure also influenced whether participants considered the situation rape in non-consensual scenarios. In additional experiments, we analysed the results by gender, manipulated perspective (being the subject or initiator of the encounter), levels of aggression, and compared the results to a group of participants who had viewed an anti-abuse campaign. Male participants and those higher in benevolent sexism were more likely than women to utilise pleasure and wantedness in judging whether situations described rape. Perspective and viewing the media campaign did not significantly affect judgements of rape. Our results have implications for models of the consequences of consent, wantedness, and pleasure of sex, and important implications for educational programmes aimed at reducing sexual assault and training for those involved in criminal justice

Perfectionism and achievement goals in young Finnish ice-hockey players aspiring to make the Under-16 national team

Research on perfectionism suggests that is it useful to differentiate between perfectionistic strivings and perfectionistic concerns. Regarding the 2 x 2 achievement goal framework, the usefulness of this differentiation was recently demonstrated in a study with university student athletes (Stoeber, Stoll, Pescheck, & Otto, 2008, Study 2), in which it was found that perfectionistic strivings were associated with mastery-approach and performance-approach goals and perfectionistic concerns with mastery-avoidance, performance-approach, and performance-avoidance goals. Because the study was largely exploratory and only used non-elite athletes, the aim of the present research was to replicate and extend these findings by investigating a sample of 138 young, elite ice-hockey players, while adding further measures of perfectionism and using structural equation modelling (SEM) to confirm the relationships between perfectionistic strivings, perfectionistic concerns,and the 2 x 2 achievement goals. The SEM results showed that, in elite athletes also, perfectionistic strivings are associated with mastery-approach and performance-approach goals, whereas perfectionistic concerns are associated with masteryavoidance, performance-approach, and performance-avoidance goals. Our findings corroborate the importance of differentiating between perfectionistic strivings and perfectionistic concerns when studying perfectionism in sports, because only perfectionistic concerns (and not perfectionistic strivings) are associated with maladaptive patterns of achievement goals

Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial

IMPORTANCE: Secretory phospholipase A2(sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes is unknown. OBJECTIVE: To determine the effects of sPLA2inhibition with varespladib on cardiovascular outcomes. DESIGN, SETTING, AND PARTICIPANTS: A double-blind, randomized, multicenter trial at 362 academic and community hospitals in Europe, Australia, New Zealand, India, and North America of 5145 patients randomized within 96 hours of presentation of an acute coronary syndrome (ACS) to either varespladib (n = 2572) or placebo (n = 2573) with enrollment between June 1, 2010, and March 7, 2012 (study termination on March 9, 2012). INTERVENTIONS: Participants were randomized to receive varespladib (500 mg) or placebo daily for 16 weeks, in addition to atorvastatin and other established therapies. MAIN OUTCOMES AND MEASURES: The primary efficacy measurewas a composite of cardiovascular mortality, nonfatal myocardial infarction (MI), nonfatal stroke, or unstable angina with evidence of ischemia requiring hospitalization at 16 weeks. Six-month survival status was also evaluated. RESULTS: At a prespecified interim analysis, including 212 primary end point events, the independent data and safety monitoring board recommended termination of the trial for futility and possible harm. The primary end point occurred in 136 patients (6.1%) treated with varespladib compared with 109 patients (5.1%) treated with placebo (hazard ratio [HR], 1.25; 95%CI, 0.97-1.61; log-rank P = .08). Varespladib was associated with a greater risk of MI (78 [3.4%] vs 47 [2.2%]; HR, 1.66; 95%CI, 1.16-2.39; log-rank P = .005). The composite secondary end point of cardiovascular mortality, MI, and stroke was observed in 107 patients (4.6%) in the varespladib group and 79 patients (3.8%) in the placebo group (HR, 1.36; 95% CI, 1.02-1.82; P = .04). CONCLUSIONS AND RELEVANCE: In patients with recent ACS, varespladib did not reduce the risk of recurrent cardiovascular events and significantly increased the risk of MI. The sPLA2inhibition with varespladib may be harmful and is not a useful strategy to reduce adverse cardiovascular outcomes after ACS. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT01130246. Copyright 2014 American Medical Association. All rights reserved

AC loss in ReBCO pancake coils and stacks of them: modelling and measurement

Many applications of ReBCO coated conductors contain stacks of pancake coils. In order to reduce their high AC loss, it is necessary to understand the loss mechanisms. In this article, we measure and simulate the AC loss and the critical current, I_c, in stacks of pancake coils ("pancakes"). We construct stacks of up to 4 pancakes and we measure them by electrical means. We also obtain the anisotropic field dependence of J_c from I_c measurements of the tape. This J_c is the only input to the simulations, together with the coil dimensions. After validating our computations with the measurements, we simulate stacks of many pancakes, up to 32. We found that the AC loss in a stack of (four) pancakes is very high, two orders of magnitude larger than for a single tape. A double pancake behaves as a single one with double width but a stack of more pancakes is very different. Finally, we found that a 2-strand Roebel cable reduces the AC loss in a stack of pancakes but not in a single pancake. In conclusion, the AC loss in stacks of pancakes is too high. However, our simulations are useful to predict the AC loss and optimise the coil design, reducing the AC loss.Comment: 34 pages, 18 figures. All figures are modified; figures 3, 7 and 10 are new. Text thoroughly revised and extende